introduction
In the following blog post, we would like to inform you about the latest development in research substances: 1S LSD, the legal successor to 1D LSD. We will not only explain the new derivative here, but also outline the key differences from its predecessor. First of all, it should be clear: 1S LSD is a research chemical and should only be studied in a scientific setting under laboratory conditions.
What is 1S LSD?
1S LSD, also known as 1-(3-(trimethylsilyl)propionyl)-lysergic acid diethylamide, is a substance belonging to the lysergamide class. It acts as a derivative of the substance LSD. 1S LSD was developed to circumvent recent legal restrictions on similar chemicals, such as 1D LSD, which were banned in Germany through an amendment to the NpSG law in June 2024. The addition of a trimethylsilyl group allows 1S LSD to be sold legally, as it is not covered by current NpSG regulations because it is a new chemical. As of February 2025, 1S LSD is legal in Germany, allowing its use for scientific purposes and research.
Chemical and experimental differences
The chemical differences between 1S LSD and 1D LSD lie in their attached groups:
- 1D LSD has a 1,2-dimethylcyclobutane-1-carbonyl group, a cyclic hydrocarbon structure.
- 1S LSD, on the other hand, has a 3-(trimethylsilyl)propionyl group, which contains a silicon atom with three methyl groups connected by a propionyl chain.
At first glance, both substances appear quite similar, but not identical in terms of their individual groups. Their extreme similarity to LSD and other LSD analogues makes them valuable tools for research. It is precisely this similarity that allows for experimental results that are very similar to those obtained with illegal LSD analogues, allowing for conclusions to be drawn about their effects.
Important legal information
First things first: The use of 1S LSD is not illegal. However, we expressly point out that the products in our store are intended exclusively for scientific and experimental purposes. We advise against any kind of use. To illustrate the potential consequences of misuse, we refer to the experiences of Albert Hoffmann, the discoverer of LSD. His unintentional self-experiment demonstrated the powerful and unpredictable properties of LSD, which can lead to dangerous situations.
Comparison of substances
A detailed comparison of 1D LSD and 1S LSD shows the following differences:
| aspect | 1D LSD | 1S LSD |
|---|---|---|
| Chemical formula | C26H33N3O2 | C28H38N3O2Si |
| Attached group | 1,2-Dimethylcyclobutane-1-carbonyl group | 3-(Trimethylsilyl)propionyl group |
| Legality (as of February 2025) | Banned in Germany since June 2024 | Currently legal in Germany |
| stability | Less information, less stable | Possibly more stable due to trimethylsilyl |
| Molar mass |
433.596 g mol−1 |
526.7 g mol−1 |
This comparison is particularly relevant with regard to the reproducibility and quality of the experiments and serves to compare the two chemicals.
Scientific and experimental use
1S LSD offers researchers the opportunity to study the properties and biological effects of LSD analogues in a controlled environment without fear of the legal consequences associated with the use of classic LSD. The highest possible quality, precision, and reproducibility of results are crucial, and our product is certified to meet these standards. Experiments have shown that research with 1S LSD can be conducted cleanly and leads to reliable results, underscoring its suitability for scientific purposes.
Our product
We offer 1S LSD in the highest possible quality, perfect for precise scientific and experimental purposes. Our product is certified and guarantees the best possible results. In our shop, you'll find various product versions, including blotters, pellets, and dropper bottles, so there's a suitable version for every experiment.
Practical information: Delivery and storage
All our products, including 1S LSD, are delivered directly to your desired address in secure and discreet packaging to ensure the quality of the substance. We recommend storing the product in a cool, dry environment, away from light and UV radiation, to ensure long-term stability. It is also important that the substance be stored in an airtight container. The Acid Berlin Safevault, which is included with the product, is perfect for this.
