In chemical research, tryptamine derivatives play a central role in the study of molecular structures and receptor interactions. At Acid Berlin, we offer legal research substances developed for controlled experiments, such as 4-PrO-MET – a synthetic tryptamine derivative. In this article, we compare 4-PrO-MET with psilocybin, a natural compound found in certain mushrooms. The focus is on scientific aspects, such as chemical structures and experimental applications, to shed light on the reproducibility and quality of such substances. We also briefly mention metocin (4-HO-MET) as a related compound, although this is not the main focus. All information is provided for informational purposes only and underscores our commitment to legal compliance.
Scientific background: 4-PrO-MET and psilocybin at a glance
4-PrO-MET, chemically known as 4-propionoxy-N-methyl-N-ethyltryptamine, is a synthetic tryptamine derivative considered a research derivative. It is produced in highly purified forms and is suitable for experiments investigating tryptamine structures. Our products undergo rigorous laboratory analyses, ensuring purity above 99%, enabling clean and reproducible experiments.
Psilocybin, on the other hand, also known as 4-phosphoryloxy-N,N-dimethyltryptamine (4-PO-DMT), is a natural substance found in Psilocybe mushrooms. It is described in the scientific literature as a prototype for tryptamine alkaloids and serves as a reference compound in studies of serotonergic systems. Unlike 4-PrO-MET, psilocybin is classified as a narcotic in many countries, including Germany, and is therefore not available for purchase.
Both substances share the basic tryptamine structure, consisting of an indole ring and an ethylamine side chain. Psilocybin carries a phosphoryl group at the 4-position, while 4-PrO-MET has a propionoxy group at the same location. These modifications make them prodrugs that can be metabolized in experimental settings—in the case of psilocybin, to psilocin (4-HO-DMT) and in the case of 4-PrO-MET, presumably to 4-HO-MET (metocin).
Comparison: Chemical Structures and Experimental Applications
Structurally, 4-PrO-MET and psilocybin share similarities that make them interesting for comparative studies. Both possess a 4-substituted tryptamine base, with varying substituents on the nitrogen atom: psilocybin has two methyl groups (N,N-dimethyl), while 4-PrO-MET carries one methyl and one ethyl group (N-methyl-N-ethyl). These differences influence molecular interactions in experiments, such as receptor binding studies. Scientific sources emphasize that 4-PrO-MET exhibits psilocybin-like properties in mouse experiments, making it a valuable alternative for legal research.
In experimental contexts, 4-PrO-MET is ideal for studies on tryptamine metabolism and stability because it is synthetically produced, thus offering consistent quality. Experiments with 4-PrO-MET are clean and reproducible, as customer feedback confirms: "The results were precise and repeatable." Psilocybin, on the other hand, is often used in studies on natural alkaloids but is less accessible due to its legal restrictions. The comparison allows researchers to analyze differences in molecular stability—for example, how the propionoxy group in 4-PrO-MET affects hydrolysis compared to the phosphoryl group in psilocybin.
Metocin (4-HO-MET) is briefly mentioned here because it is the metabolized form of 4-PrO-MET, similar to psilocin for psilocybin. It serves as a reference for hydroxylated tryptamines in research, although it is not the core of this comparison.
| aspect | 4-PrO-MET | Psilocybin |
|---|---|---|
| Chemical structure | 4-Propionoxy-N-methyl-N-ethyltryptamine | 4-Phosphoryloxy-N,N-dimethyltryptamine |
| Origin | Synthetic | Natural (from mushrooms) |
| Legal status (DE) | Legal for research purposes | narcotics, illegal |
| Experimental use | High reproducibility in laboratories | Reference in alkaloid studies |
| Purity (typical) | >99% through laboratory tests | Variable, depending on extraction |
Delivery and optimal storage of 4-PrO-MET
At Acid Berlin, we ensure the safe and discreet delivery of our research substances. 4-PrO-MET is shipped in neutral packaging, with a delivery time of 1–3 business days. We use our specially designed savevaults to ensure the best possible storage.
For storage: Store 4-PrO-MET in a cool, dry place in an airtight container, at temperatures below 20°C and away from light and moisture. These measures prevent degradation and keep the substance suitable for long-term experimentation, similar to other tryptamines such as 1S-LSD—a legal LSD analogue.
Important warnings: Responsible use and legal information
All Acid Berlin products, including 4-PrO-MET, are intended exclusively for scientific purposes. Consumption is prohibited and strictly discouraged by us. Abuse carries significant risks, as the historical example of Albert Hofmann demonstrates: In 1943, the chemist experienced uncontrollable effects after accidentally ingesting an LSD derivative, highlighting the dangers of unprofessional handling. Scientific literature warns of similar risks with tryptamines.
Psilocybin is classified as a controlled substance and may not be consumed. Use 4-PrO-MET only in controlled laboratory settings and consult legal experts if you have any questions.
Conclusion: Discovering potential for research
The comparison between 4-PrO-MET and psilocybin highlights fascinating structural parallels and differences that are important in scientific chemistry. While psilocybin serves as a natural reference, 4-PrO-MET offers a legal alternative for reproducible experiments. Explore these differences in your projects and benefit from the quality of our products.
Visit our shop to purchase 4-PrO-MET or other substances such as 1S-LSD – a legal LSD analogue.
